Bad Bug Book U.S. Food & Drug Administration
Center for Food Safety & Applied Nutrition

Foodborne Pathogenic Microorganisms
and Natural Toxins Handbook
 

Enteroinvasive Escherichia coli
Morbidity and Mortality Weekly Reports on Enteroinvasive Escherichia coli at Centers for Disease Control  NIH/PubMed: Current Research on Enteroinvasive Escherichia coli   Agricola Advanced Keyword Search of Articles on Escherichia coli - enteroinvasive

1. Name of the Organism:
Enteroinvasive Escherichia coli or (EIEC)
Currently, there are four recognized classes of enterovirulent E. coli (collectively referred to as the EEC group) that cause gastroenteritis in humans. E. coli is part of the normal intestinal flora of humans and other primates. A minority of E. coli strains are capable of causing human illness by several different mechanisms. Among these are the enteroinvasive (EIEC) strains. It is unknown what foods may harbor these pathogenic enteroinvasive (EIEC) strains responsible for a form of bacillary dysentery.
   
2. Nature of Acute Disease: Enteroinvasive E. coli (EIEC) may produce an illness known as bacillary dysentery. The EIEC strains responsible for this syndrome are closely related to Shigella spp.
   
3. Nature of Disease: Following the ingestion of EIEC, the organisms invade the epithelial cells of the intestine, resulting in a mild form of dysentery, often mistaken for dysentery caused by Shigella species. The illness is characterized by the appearance of blood and mucus in the stools of infected individuals.

Infective dose -- The infectious dose of EIEC is thought to be as few as 10 organisms (same as Shigella).

   
4. Diagnosis of Human Illness: The culturing of the organism from the stools of infected individuals and the demonstration of invasiveness of isolates in tissue culture or in a suitable animal model is necessary to diagnose dysentery caused by this organism.

More recently, genetic probes for the invasiveness genes of both EIEC and Shigella spp. have been developed.

   
5. Associated Foods: It is currently unknown what foods may harbor EIEC, but any food contaminated with human feces from an ill individual, either directly or via contaminated water, could cause disease in others. Outbreaks have been associated with hamburger meat and unpasteurized milk.
   
6. Relative Frequency of Disease: One major foodborne outbreak attributed to enteroinvasive E. coli in the U.S. occurred in 1973. It was due to the consumption of imported cheese from France. The disease caused by EIEC is uncommon, but it may be confused with shigellosis and its prevalence may be underestimated.
   
7. Course of Disease and Complications: Dysentery caused by EIEC usually occurs within 12 to 72 hours following the ingestion of contaminated food. The illness is characterized by abdominal cramps, diarrhea, vomiting, fever, chills, and a generalized malaise. Dysentery caused by this organism is generally self-limiting with no known complications. A common sequelus associated with infection, especially in pediatric cases, is hemolytic uremic syndrome (HUS).
   
8. Target Populations: All people are subject to infection by this organism.
   
9. Food Analysis: Foods are examined as are stool cultures. Detection of this organism in foods is extremely difficult because undetectable levels may cause illness. It is estimated that the ingestion of as few as 10 organisms may result in dysentery.
   
10. Selected Outbreaks: Literature references can be found at the links below.
  Several outbreaks in the U.S. have been attributed to this organism. One outbreak occurred in 1973 and was due to the consumption of imported cheese. More recently, a cruise ship outbreak was attributed to potato salad, and an outbreak occurred in a home for the mentally retarded where subsequent person-to-person transmission occurred.
Morbidity and Mortality Weekly Reports For more information on recent outbreaks see the CDC.
   
11. Education and Background Resources: None currently available.
   
12. Molecular Structural Data: None currently available.

CDC/MMWR
The CDC/MMWR link will provide a list of Morbidity and Mortality Weekly Reports at CDC relating to this organism or toxin. The date shown is the date the item was posted on the Web, not the date of the MMWR. The summary statement shown are the initial words of the overall document. The specific article of interest may be just one article or item within the overall report.
NIH/PubMed
The NIH/PubMed button at the top of the page will provide a list of research abstracts contained in the National Library of Medicine's MEDLINE database for this organism or toxin.
AGRICOLA
The AGRICOLA button will provide a list of research abstracts contained in the National Agricultural Library database for this organism or toxin.

mow@cfsan.fda.gov
January 1992 with periodic updates


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