Dimarcq, J.-L., Bulet, P., Hetru, C., Hoffmann, J. 1998 Cysteine-rich antimicrobial peptides in invertebrates. Biopolymers 47 (6), pp. 465-477

Antimicrobial peptides are pivotal elements of the innate immune defense against bacterial and fungal infections. Within the impressive list of antimicrobial peptides available at present, more than half have been characterized in arthropods. Cysteine-rich antimicrobial peptides represent the most diverse and widely distributed family among arthropods and, to a larger extent, among invertebrates. Preeminent groups of cysteine-rich peptides are peptides with the CSαβ motif and peptides forming an hairpin-like β-sheet structure. Although these substances exhibit a large structural diversity and a wide spectrum of activity, they have in common the ability to permeabilize microbial cytoplasmic membranes. Drosophila has proved a remarkable system for the analysis of the regulation of expression of gene encoding antimirobial cysteine-rich peptides. These studies have unraveled the striking parallels that exist between insect immunity and innate immunity in mammals that point to a common ancestry of essential aspects of innate immunity. © 1999 John Wiley & Sons, Inc.